Year: 2024
Type: article
Study design: Case Report
Abstract: OBJECTIVE: Generalized periodic discharges are a repeated and generalized electroencephalography (EEG) pattern that can be seen in the context of altered mental status. This article describes a series of five individuals with generalized periodic discharges who demonstrated signs and symptoms of catatonia, a treatable neuropsychiatric condition. METHODS: Inpatients with a clinical diagnosis of catatonia, determined with the Bush-Francis Catatonia Rating Scale (BFCRS), and EEG recordings with generalized periodic discharges were analyzed in a retrospective case series. RESULTS: Five patients with catatonia and generalized periodic discharges on EEG were evaluated from among 106 patients with catatonia and contemporaneous EEG measurements. Four of these patients showed an improvement in catatonia severity when treated with benzodiazepines, with an average reduction of 6.75 points on the BFCRS. CONCLUSIONS: Among patients with generalized periodic discharges, catatonia should be considered, in the appropriate clinical context. Patients with generalized periodic discharges and catatonia may benefit from treatment with empiric trials of benzodiazepines.
Source: Journal of Neuropsychiatry
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: National Science Foundation, Johns Hopkins University, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Multimodal Network Connectivity Architecture (MOCA) of the Brain and its Role in the Recovery of Consciousness in Comatose Cardiac Arrest Patients, Translational Neuroscience Training for Clinicians, SCH: INT: Collaborative Research: DeepSense: Interpretable Deep Learning for Zero-effort Phenotype Sensing and Its Application to Sleep Medicine, Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt, Establishing a Brain Health Index, Investigation of Sleep, Integrative Motor Activity Biomarker for the Risk of Alzheimer's Risk, Big Data and Deep Learning for the Interictal-Ictal-Injury Contiuum, Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention, Comparative Safety of Seizure Prophylaxis within the Medicare Program, Data-Driven Sleep Biomarkers of Brain Health, Heart Health, and Mortality, Prospective Validation of Neurophysiologic Outcome Prediction in Acute Brain Injury
OpenAlex ID: W4396774837