Work

Duplex-forming oligocarbamates with tunable nonbonding sites

Year: 2024

Type: article

Abstract: Sequence-defined oligocarbamates with thymine and diaminotriazine pendant groups assemble into duplexes. The binding strength ( K a ), enthalpy (Δ H ), and entropy (Δ S ) of hybridization depend on the valency and sequence of the interacting ligands.

Source: Chemical Science

DOI: 10.1039/d4sc00242c

Authors: R. Kenton Weigel, Christopher A. Alabi

Institution: Cornell University

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: National Science Foundation, Division of Chemistry

Awards: G1134277896, G2079003132, Sequence Programmable Triazine-Thymine Synthetic Ligands, MRI: Acquisition of a Cryogenic Probe and Modern Console for Outstanding NMR Sensitivity to Benefit Research and Education at Cornell University, G8389919011