Work

LncRNAs, nuclear architecture and the immune response

Year: 2024

Type: article

Abstract: Long noncoding RNAs (LncRNAs) are key regulators of gene expression and can mediate their effects in both the nucleus and cytoplasm. Some of the best-characterized lncRNAs are localized within the nucleus, where they modulate the nuclear architecture and influence gene expression. In this review, we discuss the role of lncRNAs in nuclear architecture in the context of their gene regulatory functions in innate immunity. Here, we discuss various approaches to functionally characterize nuclear-localized lncRNAs and the challenges faced in the field.

Source: Nucleus

DOI: 10.1080/19491034.2024.2350182

Authors: Christy Montano, Cristina Flores-Arenas, Susan Carpenter

Institution: University of California, Santa Cruz

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,993

Funders: National Institutes of Health, National Institute of General Medical Sciences