Work

FIGURE 2 from Mutant RAS-driven Secretome Causes Skeletal Muscle Defects in Breast Cancer

Year: 2024

Type: other

Abstract: The effects of PDXs on plasma miR-486 and functional markers in skeletal muscle. A, A significant decline in circulating miR-486 levels was observed across all PDX subtypes. B, Differential effects of PDX subtypes on miR-486 in skeletal muscles of mice. C, Differential impact of PDXs on skeletal muscle Pax7. D, Differential impact of PDXs on skeletal muscle MyoD. E, The effect of PDXs on skeletal muscle Myh1. F, The effect of PDXs on skeletal muscle p53. G, ER+/PR+ and ER+/PR− tumor-derived PDXs increased skeletal muscle Pdk4, compared with TNBC PDXs.

DOI: 10.1158/2767-9764.25826875.v1

Authors: Ruizhong Wang, Aditi S. Khatpe, Brijesh Kumar, Henry Elmer Mang, Katie Batic, Adedeji K. Adebayo, Harikrishna Nakshatri

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4396938784

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