Gut Microbiome Multi-Omics and Cognitive Function in the Hispanic Community Health Study/Study of Latinos- Investigation of Neurocognitive Aging
Year: 2024
Type: preprint
Study design: Observational Study
Abstract: INTRODUCTION: conducted a study within the Hispanic Community Health Study/Study of Latinos- Investigation of Neurocognitive Aging (HCHS/SOL-INCA) cohort to examine the association between gut microbiome and cognitive function. METHODS: We analyzed the fecal metagenomes of 2,471 HCHS/SOL-INCA participants to, cross-sectionally, identify microbial taxonomic and functional features associated with global cognitive function. Omnibus (PERMANOVA) and feature-wise analyses (MaAsLin2) were conducted to identify microbiome-cognition associations, and specific microbial species and pathways (Kyoto Encyclopedia of Genes and Genomes (KEGG modules) associated with cognition. RESULTS: ), were associated with better cognition. Several KEGG modules, most strongly Ornithine, Serine biosynthesis and Urea Cycle, were associated with worse cognition. DISCUSSION: In a large Hispanic/Latino cohort, we identified several microbial taxa and KEGG pathways associated with cognition.
Source: medRxiv
Institutions: University of Massachusetts Lowell, Harvard University, VA New England Healthcare System, Albert Einstein College of Medicine, Broad Institute, University of California San Diego, University of California, Davis, University of Illinois Chicago, Rush University, San Diego State University, Wayne State University, Sano – Centre for Computational Personalised Medicine International Research Foundation, University of North Carolina at Chapel Hill
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: National Institute on Aging
OpenAlex ID: W4397044047