Crosstalk between histone/DNA modifications and RNA N6-methyladenosine modification
Year: 2024
Type: review
Abstract: N6-methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotic messenger RNAs (mRNAs), regulating gene expression at the transcription and post-transcription levels. Complex interplay between m6A and other well-studied epigenetic modifications, including histone modifications and DNA modification, has been extensively reported in recent years. The crosstalk between RNA m6A modification and histone/DNA modifications plays a critical role in establishing the chromatin state for the precise and specific fine-tuning of gene expression and undoubtedly has profound impacts on both physiological and pathological processes. In this review, we discuss the crosstalk between RNA m6A modification and histone/DNA modifications, emphasizing their sophisticated communications and the mechanisms underlying to gain a comprehensive view of the biological relevance of m6A-based epigenetic network.
Authors: Yushuai Wang, Huilin Huang, Jianjun Chen, Hengyou Weng
Institutions: Guangzhou Laboratory, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, City Of Hope National Medical Center, City of Hope, Beckman Research Institute, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, State Key Laboratory of Respiratory Disease, Guangzhou Medical University
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,050
OpenAlex ID: W4398189889