Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: We recently identified three distinct Parkinson's disease subtypes: "motor only" (predominant motor deficits with intact cognition and psychiatric function); "psychiatric & motor" (prominent psychiatric symptoms and moderate motor deficits); "cognitive & motor" (cognitive and motor deficits). OBJECTIVE: We used an independent cohort to replicate and assess reliability of these Parkinson's disease subtypes. METHODS: We tested our original subtype classification with an independent cohort (N = 100) of Parkinson's disease participants without dementia and the same comprehensive evaluations assessing motor, cognitive, and psychiatric function. Next, we combined the original (N = 162) and replication (N = 100) datasets to test the classification model with the full combined dataset (N = 262). We also generated 10 random split-half samples of the combined dataset to establish the reliability of the subtype classifications. Latent class analyses were applied to the replication, combined, and split-half samples to determine subtype classification. RESULTS: First, LCA supported the three-class solution - Motor Only, Psychiatric & Motor, and Cognitive & Motor- in the replication sample. Next, using the larger, combined sample, LCA again supported the three subtype groups, with the emergence of a potential fourth group defined by more severe motor deficits. Finally, split-half analyses showed that the three-class model also had the best fit in 13/20 (65%) split-half samples; two-class and four-class solutions provided the best model fit in five (25%) and two (10%) split-half replications, respectively. CONCLUSIONS: These results support the reproducibility and reliability of the Parkinson's disease behavioral subtypes of motor only, psychiatric & motor, and cognitive & motor groups.
Source: Parkinsonism & Related Disorders
Institution: Washington University in St. Louis
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,630
Funders: Mallinckrodt Institute of Radiology, School of Medicine, Washington University in St. Louis, U.S. Department of Defense, Michael J. Fox Foundation for Parkinson's Research, Huntington's Disease Society of America, American Brain Foundation, American Academy of Neurology, Biogen, CHDI Foundation, American Parkinson Disease Association, Washington University in St. Louis, Foundation for Barnes-Jewish Hospital, National Institutes of Health, McDonnell Center for Systems Neuroscience, National Institute on Aging, National Institute of Mental Health, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, National Center for Research Resources, National Center for Advancing Translational Sciences, National Center for Complementary and Integrative Health, Dystonia Coalition
Awards: G1141458775, Dystonia Coalition, PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTER, G1244773649, Parkinson Disease Clinical Subtypes: Validation, Clinical Utility, and Biological Correlates, Investigations of Dementia in Parkinson Disease, G1850433981, Imaging Ligands for Alpha-Synuclein Fibril Accumulation in Multiple System Atrophy, G1940988305, G2206977757, Dystonia Coalition, Neuroimaging of PDE10A, G2479984328, Washington University Network of Excellence in Neuroscience Clinical Trials Site, G2686484853, G2706664256, G2879181683, G3152249624, G3243741457, G3342485756, G3642418395, G3885130535, G4065944152, G4161205564, NOVEL PET TRACERS FOR IMAGING OF ALZHEIMER'S DISEASE, Strategy-based cognitive intervention for Parkinson disease: A pilot randomized controlled trial, G4369482233, G443981674, Neuroinflammatory Biomarkers for Nigrostriatal Injury, G4710965566, G4990936925, G5177640449, NOVEL PET MARKERS OF COGNITIVE IMPAIRMENT IN MANGANESENEUROTOXICITY, Dystonia Coalition, Factors that Contribute to Hearing Handicap and Hearing Loss Treatment Decisions of Older Adults, Understanding engagement in research, clinical care, and community services among people of color with Parkinson disease, Structural Biology of Alpha-Synuclein in Lewy Body Dementia, G6307657801, G6389252386, Intergenerational Transmission of Stress: Psychosocial and Biological Mechanisms, G6637773844, POSTMORTEM VALIDATION OF BIOMARKERS FOR IMAGING PARKINSON DISEASE, Investigations of Dementia in Parkinson Disease, Prospective memory impairment in Parkinson disease-related cognitive decline: Intervention and mechanisms, G7323041747, Cortical Network Modulation by Subthalamic Nucleus Deep Brain Stimulation, Protein Aggregation and Neurotransmitter Deficits in Parkinson Disease, G7797540627, Washington University Institute of Clinical and Translational Sciences (UL1), G7967294566, Moving Mindfully: A MBSR-Centered Approach to Freezing in Parkinson Disease, G8191042871, Sing for Your Saunter: Using Self-Generated Rhythmic Cues to Enhance Gait in Parkinson's, G8460413203, G8602904375, G8714967758, Development and Translation of a PET Tracer for Specific and Early Detection of Alzheimer's Disease, STRUCTURAL BIOLOGY OF ALPHA-SYNUCLEIN IN LEWY BODY DEMENTIA, EARLY PREDICTORS OF BRAIN HEALTH AND DEVELOPMENT IN YOUTH WITH T1DM, G8960086504, G9000076568, G9000184226, G9000204826, G9000238777, G9000265048, North American Prodromal Synucleinopathy Consortium for RBD, Stage 2 (NAPS2), Precision-Mapping Functional Connectivity in Parkinson's Disease, Brain Health Across the Metabolic Continuum in Youth at Risk for T2D, Center without Walls for Imaging Proteinopathies with PET, Washington University Institute of Clinical and Translational Sciences (KL2), Cerebellar cholinergic connections as a biomarker of dementia and gait impairment in Parkinson disease, Sing for Your Saunter: Using Self-Generated Rhythmic Cues to Enhance Gait in Parkinson's, Multi-tissue High-throughput Proteomic and Genomic Study in Parkinson's Disease, G964793895
OpenAlex ID: W4398200621