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Controlled oxygen delivery to power tissue regeneration

Year: 2024
Type: article
Abstract: Oxygen plays a crucial role in human embryogenesis, homeostasis, and tissue regeneration. Emerging engineered regenerative solutions call for novel oxygen delivery systems. To become a reality, these systems must consider physiological processes, oxygen release mechanisms and the target application. In this review, we explore the biological relevance of oxygen at both a cellular and tissue level, and the importance of its controlled delivery via engineered biomaterials and devices. Recent advances and upcoming trends in the field are also discussed with a focus on tissue-engineered constructs that could meet metabolic demands to facilitate regeneration.
DOI: 10.1038/s41467-024-48719-x
Authors: Elizabeth Zoneff, Yi Wang, Colin Jackson, Oliver Smith, Serena Duchi, Carmine Onofrillo, Brooke Farrugia, Simon E. Moulton, Richard Williams, Clare Parish, David R. Nisbet, Lilith M. Caballero-Aguilar
Institutions: The University of Melbourne, Australian National University, ARC Centre of Excellence in Synthetic Biology, St Vincent's Hospital Melbourne, Swinburne University of Technology, Deakin University, Florey Institute of Neuroscience and Mental Health
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: gold
Estimated APC paid: $6,790
OpenAlex ID: W4398201307
FWCI: 33.05
Cites: 155
Cited by: 87
Related to: 10