Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk

Year: 2024

Type: article

Abstract: In-utero and dietary factors make important contributions toward health and development in early childhood. In this respect, serum proteomics of maturing infants can provide insights into studies of childhood diseases, which together with perinatal proteomes could reveal further biological perspectives. Accordingly, to determine differences between feeding groups and changes in infancy, serum proteomics analyses of mother-infant dyads with HLA-conferred susceptibility to type 1 diabetes ( n = 22), weaned to either an extensively hydrolyzed or regular cow's milk formula, were made. The LC-MS/MS analyses included samples from the beginning of third trimester, the time of delivery, 3 months postpartum, cord blood, and samples from the infants at 3, 6, 9, and 12 months. Correlations between ranked protein intensities were detected within the dyads, together with perinatal and age-related changes. Comparison with intestinal permeability data revealed a number of significant correlations, which could merit further consideration in this context.

Source: iScience

DOI: 10.1016/j.isci.2024.110048

Authors: Santosh D. Bhosale, Robert Moulder, Tomi Suomi, Terhi Ruohtula, Jarno Honkanen, Suvi M. Virtanen, Jorma Ilonen, Laura L. Elo, Mikael Knip, Riitta Lahesmaa

Institutions: Åbo Akademi University, University of Turku, University of Helsinki, Tampere University, Finnish Institute for Health and Welfare, Tampere University Hospital, University of Tampere

Language: English

Topic: Infant Nutrition and Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: gold

Estimated APC paid: $3,770

Funders: Juvenile Diabetes Research Foundation International, Helsingin ja Uudenmaan Sairaanhoitopiiri, Juvenile Diabetes Research Foundation United States of America, Academy of Finland, Jane ja Aatos Erkon Säätiö, Turun Yliopisto, Sigrid Juséliuksen Säätiö, Syöpäjärjestöt, Diabetesliitto, Biocenter Finland, Business Finland, Turun yliopiston tutkijakoulu, H2020 European Research Council, JDRF

OpenAlex ID: W4398220655