Work

Neutrophil reduction attenuates the severity of lung injury in the early phase of pneumococcal pneumonia in mice

Year: 2024

Type: article

Abstract: Neutrophil accumulation is a key feature of ARDS, but their contribution to the pathogenesis is still uncertain. We investigated the effect of reducing neutrophils in a clinically relevant mouse model of pneumococcal pneumonia treated with antibiotics. When appropriate antibiotics were administered, neutrophil reduction with Ly6G antibody markedly attenuated lung injury and improved oxygenation. In the early phase of bacterial pneumonia, neutrophils contribute to the severity of lung injury, although they also participate in host defense.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00113.2024

Authors: Hiroki Taenaka, Xiaohui Fang, Mazharul Maishan, Alpa Trivedi, Katherine D. Wick, Jeffrey E. Gotts, Thomas R. Martin, Carolyn S. Calfee, Michael A. Matthay

Institutions: University of California, San Francisco, The University of Osaka, Mayo Clinic, University of Washington

Language: English

Topic: Respiratory Support and Mechanisms

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Alcohol Abuse and Alcoholism, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G13806056, G3034153513, Precision Medicine in the Acute Respiratory Distress Syndrome, Prevention and Early Treatment of Acute Lung Injury, Diabetes Research Center, Comprehensive Anesthesia Research Training, CoPARC: Colorado Pulmonary-Alcohol Research Collaborative

OpenAlex ID: W4398221442

FWCI: 4.388

Cites: 49

Cited by: 16

Related to: 10