Work

Cognitive performance and mortality among patients receiving autologous hematopoietic stem cell transplant

Year: 2024

Type: article

Abstract: OBJECTIVES: Patients undergoing autologous hematopoietic stem cell transplant (HCT) are at risk for death and remain understudied relative to those undergoing allogeneic HCT. Cognitive functioning may be a useful indicator of mortality risk. We examined cognition among patients who underwent autologous HCT and its relationship to mortality. METHODS: = 51; 11 patients deceased) completed tasks of processing speed, working memory, executive-mediated learning, and visual recall using the computerized CogState battery prior to HCT, 30 days post-autologous HCT, and 100 days post-autologous HCT. RESULTS: Slower processing speed (HR = 3.00) and more errors on an executive-mediated visual learning task (HR = 2.78) prior to HCT were associated with an increased risk of death following HCT. Our sample size limited longitudinal analyses of whether cognitive change predicted survival, however descriptive cognitive data of the deceased versus living patient's performances over time suggested different patterns of performance across groups. CONCLUSIONS: Pre-HCT cognition may have utility as an indicator of mortality risk following autologous HCT. More research is needed to examine whether cognitive changes after HCT could also predict mortality.

Source: Journal of Psychosocial Oncology

DOI: 10.1080/07347332.2024.2342843

Authors: Ellen Johnson, Sung Won Choi, John Stratton, Alison Sylvia, Flora Hoodin, Kristen Votruba

Institutions: University of Michigan, Michigan Medicine, University of Wisconsin–Madison, University of Cincinnati

Language: English

Topic: Cancer-related cognitive impairment studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Blue Cross Blue Shield of Michigan Foundation, National Heart, Lung, and Blood Institute