Reviewer #1 (Public Review): A Connectome of the Male Drosophila Ventral Nerve Cord
Year: 2024
Type: peer-review
Abstract: Animal behavior is principally expressed through neural control of muscles. Therefore understanding how the brain controls behavior requires mapping neuronal circuits all the way to motor neurons. We have previously established technology to collect large-volume electron microscopy data sets of neural tissue and fully reconstruct the morphology of the neurons and their chemical synaptic connections throughout the volume. Using these tools we generated a dense wiring diagram, or connectome, for a large portion of the Drosophila central brain. However, in most animals, including the fly, the majority of motor neurons are located outside the brain in a neural center closer to the body, i.e. the mammalian spinal cord or insect ventral nerve cord (VNC). In this paper, we extend our effort to map full neural circuits for behavior by generating a connectome of the VNC of a male fly.
Source: eLife
Authors: Shin-ya Takemura, Kenneth J Hayworth, Gary B Huang, Michal Januszewski, Zhiyuan Lu, Elizabeth C Marin, Stephan Preibisch, C Shan Xu, John Bogovic, Andrew S Champion, Han SJ Cheong, Marta Costa, Katharina Eichler, William Katz, Christopher Knecht, Feng Li, Billy J Morris, Christopher Ordish, Patricia K Rivlin, Philipp Schlegel, Kazunori Shinomiya, Tomke Stürner, Ting Zhao, Griffin Badalamente, Dennis Bailey, Paul Brooks, Brandon S Canino, Jody Clements, Michael Cook, Octave Duclos, Christopher R Dunne, Kelli Fairbanks, Siqi Fang, Samantha Finley-May, Audrey Francis, Reed George, Marina Gkantia, Kyle Harrington, Gary Patrick Hopkins, Joseph Hsu, Philip M Hubbard, Alexandre Javier, Dagmar Kainmueller, Wyatt Korff, Julie Kovalyak, Dominik Krzemiński, Shirley A Lauchie, Alanna Lohff, Charli Maldonado, Emily A Manley, Caroline Mooney, Erika Neace, Matthew Nichols, Omotara Ogundeyi, Nneoma Okeoma, Tyler Paterson, Elliott Phillips, Emily M Phillips, Caitlin Ribeiro, Sean M Ryan, Jon Thomson Rymer, Anne K Scott, Ashley L Scott, David Shepherd, Aya Shinomiya, Claire Smith, Natalie Smith, Alia Suleiman, Satoko Takemura, Iris Talebi, Imaan FM Tamimi, Eric T Trautman, Lowell Umayam, John J Walsh, Tansy Yang, Gerald M Rubin, Louis K Scheffer, Jan Funke, Stephan Saalfeld, Harald F Hess, Stephen M Plaza, Gwyneth M Card, Gregory SXE Jefferis, Stuart Berg
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W4398470448