Longitudinal plasma proteomic analysis of 1117 hospitalized patients with COVID-19 identifies features associated with severity and outcomes
Year: 2024
Type: article
Study design: Observational Study
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by highly heterogeneous manifestations ranging from asymptomatic cases to death for still incompletely understood reasons. As part of the IMmunoPhenotyping Assessment in a COVID-19 Cohort study, we mapped the plasma proteomes of 1117 hospitalized patients with COVID-19 from 15 hospitals across the United States. Up to six samples were collected within ~28 days of hospitalization resulting in one of the largest COVID-19 plasma proteomics cohorts with 2934 samples. Using perchloric acid to deplete the most abundant plasma proteins allowed for detecting 2910 proteins. Our findings show that increased levels of neutrophil extracellular trap and heart damage markers are associated with fatal outcomes. Our analysis also identified prognostic biomarkers for worsening severity and death. Our comprehensive longitudinal plasma proteomics study, involving 1117 participants and 2934 samples, allowed for testing the generalizability of the findings of many previous COVID-19 plasma proteomics studies using much smaller cohorts.
Source: Science Advances
Authors: Arthur Viode, Kinga K. Smolen, Patrick van Zalm, David Stevenson, Meenakshi Jha, Kenneth Parker, IMPACC Network‡, Ofer Levy, Judith A. Steen, Hanno Steen
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,500
Awards: Integrative Omics of HepB Vaccine Response in Co-Infection with Parasites, FUNGAL PATHOGENESIS OF MODERATE TO SEVERE ASTHMA, High-throughput proteomics using submicroliter amounts of plasma for comprehensive assessment of the immune status, Systems Biology to Identify Biomarkers of Neonatal Vaccine Immunogenicity, Long Term Immunity Following Yellow Fever Vaccination, Dengue Human Immunology Project Consortium (DHIPC), System Biological Analyses of Innate and Adaptive Responses to Vaccination, Molecular and Immunologic Analysis of the Pathobiology of Human Anthrax, Mapping Immune Responses to CMV in Renal Transplant Recipients, A 3D Tissue Map of the Human Lymphatic System, Discriminating the contributions of CCR4 and CCR7 to thymic central tolerance, Integrated Platform to study Neurodegeneration in Alzheimer’s Disease, Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro, Immune-driven Airway Epithelial Dysfunction in Muco-obstructive Asthma, Innate Immunity and Viral Infection in Asthma, Immune signatures of vaccine responses in vulnerable populations
OpenAlex ID: W4398764784