Work

Identification of genes regulated by Rcor1 in CD71+, TER119- erythroid progenitors using mRNA-seq analysis

Year: 2020

Type: dataset

Abstract: Transcription cofactor Rcor1 has been linked biochemically both to neurogenesis and hematopoiesis. Here we studied the function of Rcor1 in vivo and showed it is essential to erythropoeisis during embryonic development. Rcor1 mutant proerythroblasts, unlike normal cells, can form myeloid colonies in vitro. To investigate the underlying molecular mechanisms for block of erythropoiesis and increased myeloid potential, we used RNA-seq to reveal the differentially expressed genes from erythroid progenitors due to depletion of Rcor1.

Source: Harvard Dataverse

DOI: 10.7910/dvn/rgpbwn

Authors: Yao, Huilan, Goldman, Devorah C., Nechiporuk, Tamilla, Kawane, Sunita, McWeeney, Shannon K., Tyner, Jeffrey W., Fan, Guang, Kerenyi, Marc A., Orkin, Stuart H., Fleming, William H., Mandel, Gail

Institutions: Vollum Institute, OHSU Knight Cancer Institute, Oregon Health & Science University, Boston Children's Hospital, Harvard University, Harvard Stem Cell Institute

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4398884446

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