Work

Unraveling the roles of ectopic adipose depots and physical activity in age‐related mitochondrial decline

Year: 2024

Type: article

Abstract: Age-related changes in body composition, including loss of lean mass, increases in adiposity, and preferential redistribution of adipose tissue to ectopic depots, are some of the most vexing aspects of aging.Indeed, these age-related changes in body composition contribute to increased risk of cardiometabolic (e.g., diabetes, cardiovascular disease) as well as geriatric (e.g., sarcopenia, mobility disability, frailty) -related disorders.Recent data suggest that age-related loss of muscle mass [1], elevations in intermuscular adipose tissue (IMAT) [1], and impairments in skeletal muscle mitochondrial bioenergetics [2] are associated with impairments in mobility and subsequent development of frailty.However, the link among age-related changes in skeletal muscle, adipose tissue, and mitochondrial function remains incompletely understood.In addition, age-related changes in physical activity likely mediate changes in skeletal muscle mass, adiposity, and measures of mitochondrial bioenergetics.

Source: Obesity

DOI: 10.1002/oby.24048

Authors: Brian A. Irving, Hawley E. Kunz

Institutions: Pennington Biomedical Research Center, Louisiana State University, Mayo Clinic

Language: English

Topic: Adipose Tissue and Metabolism

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Diabetes and Digestive and Kidney Diseases