3D-printed porous zinc scaffold combined with bioactive serum exosomes promotes bone defect repair in rabbit radius
Year: 2024
Type: article
Abstract: experiments on rabbits indicated that the hepatic and renal toxicity of the zinc scaffold decreased over time, and the loading of exosomes alleviated the hepatic and renal toxic effects of the zinc scaffold. Throughout various stages of repairing radial bone defects in rabbits, loading exosomes reinforced the zinc scaffold's capacity to enhance osteogenic cell activity, suppress osteoclast activity, and promote angiogenesis. This effect may be attributed to BF Exo's regulation of p38/STAT1 signaling. This study signifies that the combined treatment of degradable porous zinc scaffolds and BF Exo is an effective and biocompatible strategy for bone defect repair therapy.
Source: Aging
Authors: Baoxin Zhang, Zhiwei Pei, Wanxiong He, Wei Feng, Ting Hao, Mingqi Sun, Xiaolong Yang, Xing Wang, Xiangyu Kong, Jiale Chang, Guanghui Liu, Rui Bai, Chang Wang, Feng Zheng
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Award: G3105611153
OpenAlex ID: W4399210188