Capturing heterogeneity in PDX models: representation matters
Year: 2024
Type: article
Abstract: Patient derived tumor xenografts (PDXs) are important models for pre-clinical testing in cancer research and personalized medicine. PDXs often represent patient tumors with high similarity in terms of histology and driver mutations. However, certain limitations exist that warrant a detailed understanding of PDX heterogeneity and evolution. Hynds et al. demonstrate the relevance of primary tumor heterogeneity in PDX model establishment and explore multi-region sampling to determine the extent to which PDXs represent primary tumors.
Source: Nature Communications
Authors: Hari Shankar Sunil, Kathryn A. O’Donnell
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,790
Awards: G1043272518, G1782948627, G278188391, G4126749349, G5265223662, G5500639729, Immune Checkpoint Regulation by the Integrated Stress Response Pathway in Lung Cancer, Targeting Lung Cancer Vulnerabilities, G620927354, G6305647201, Development of an antibody targeting PCDH7 for lung cancer therapy, G8790053301, The role of PCDH7 in lung cancer pathogenesis, The role of translation initiation factor eIF5B in lung cancer pathogenesis
OpenAlex ID: W4399211397