FIGURE 5 from LYVE-1–expressing Macrophages Modulate the Hyaluronan-containing Extracellular Matrix in the Mammary Stroma and Contribute to Mammary Tumor Growth
Year: 2024
Type: other
Abstract: scRNA-seq identifies macrophage subsets in the tumor microenvironment. A, UMAP projection of 17 distinct clusters from the total population of CD45+ cells from EO771 tumors from Csf1rfl/fl and Lyve1CreCsf1rfl/fl mice (n = 2 per genotype) with cell-specific labels. B, Dot plot of macrophage-associated genes from cells derived from Csf1rfl/fl tumors. C, Dot plot of enriched genes in macrophage clusters. D, Intercluster GSEA from Csf1rfl/fl macrophage clusters [normalized enrichment scale (NES) adjusted P-value < 0.05] with detailed gene set names in Supplementary Table S2. E, Feature plot of Folr2 from tumors from Csf1rfl/fl and Lyve1CreCsf1rfl/fl mice. F, Average cell counts per cluster from tumors from Csf1rfl/fl and Lyve1CreCsf1rfl/fl mice. G, Waterfall plots of relative enrichment in cluster 7 Lyve1CreCsf1rfl/fl relative to Csf1rfl/fl of genes associated with glycosaminoglycan binding.
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4399212679