Oxygenation and Ventilation after Pediatric In-Hospital Cardiac Arrest: Moving Targets?
Year: 2024
Type: editorial
Abstract: Of the estimated 76% of children who are successfully resuscitated from pulseless in-hospital cardiac arrest (IHCA), roughly half do not survive to hospital discharge (1), and many of these deaths result from severe neurological sequelae (2).Of those who do survive to hospital discharge, a significant proportion are left with permanent neurological disability.For this reason, a major focus of postarrest care is to optimize conditions that promote neurologic recovery and prevent further injury, including intensive monitoring and meticulous management of blood pressure, temperature, glucose, and seizures (3).The molecular mechanisms for ongoing neurologic injury after cardiac arrest are complex and largely derived from preclinical studies, and it is unclear how to extrapolate this to humans (3, 4).Therefore, it is imperative that we identify modifiable risk factors for ongoing brain injury to ultimately improve outcomes for survivors of pediatric cardiac arrest.One question of particular interest is how oxygen and carbon dioxide (CO 2 ) concentrations may affect neuronal injury
Author: Catherine E. Ross
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4399214780