Work

FIGURE 3 from Molecular Landscape and Clinical Implication of CCNE1-amplified Esophagogastric Cancer

Year: 2024

Type: other

Abstract: Immune microenvironment and biomarker analysis of CCNE1-amplified EGC. Breakdown of immune biomarkers of CCNE1-amplified versus nonamplified EG adenocarcinoma by MMR/MSI-H status, PD-L1 (22C3) expression, and TMB high status (A). Characterization of percentage infiltration of specified immune cell populations in CCNE1-amplified versus nonamplified EGC from WTS by RNA deconvolution analysis (B). Expression of immune-related genes in CCNE1-amplified versus nonamplified from RNA sequencing (C). Immune-related gene signatures including IFNG and T cell–inflamed signatures (D). Statistical significance is displayed as the following: *, q < 0.05; **, q < 0.01; ***, q < 0.001; ****, q < 0.0001.

DOI: 10.1158/2767-9764.25958964.v1

Authors: Naryan Rustgi, Sharon Wu, Timothy Samec, Phillip Walker, Joanne Xiu, Emil Lou, Sanjay Goel, Anwaar Saeed, Ryan H. Moy

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4399287665

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