Work

Author Correction: Nuclear genetic control of mtDNA copy number and heteroplasmy in humans

Year: 2024

Type: erratum

Abstract: When performing a genome-wide association study (GWAS), the choice of which allele (reference vs. alternate) is considered the “effect allele” is arbitrary. In our computations, we chose the reference allele. For a small subset of our results, the effect sizes were erroneously attributed to the alternate allele. The conclusions in our paper are not impacted, as we only use GWAS results to make inferences regarding the presence/absence of associations (i.e., using P values).

Source: Nature

DOI: 10.1038/s41586-024-07364-6

Authors: Rahul Gupta, Masahiro Kanai, Timothy J. Durham, Kristin Tsuo, Jason G. McCoy, Anna V. Kotrys, Wei Zhou, Patrick F. Chinnery, Konrad J. Karczewski, Sarah E. Calvo, Benjamin M. Neale, Vamsi K. Mootha

Institutions: Broad Institute, Howard Hughes Medical Institute, Harvard University, Massachusetts General Hospital, University of Cambridge, MRC Mitochondrial Biology Unit

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $12,290

Funder: National Institute of General Medical Sciences

Award: Medical Scientist Training Program

OpenAlex ID: W4399290488

Cites:

Cited by: 1

Related to: 10