Supplementary Figure S5 from Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6
Year: 2024
Type: supplementary-materials
Abstract: Fig. S5. RNA sequencing of PDAC cells. (A) Volcano plot showing upregulated (1145) and downregulated (183) genes in T3M4-WT and T3M4-MUC16KO cells (n=3); (B) Gene set enrichment analysis (GSEA) plot showing enrichment of apoptosis in T3M4-MUC16KO cells. (C) Log2FoldChange (Lof2FC) of MUC16KO versus WT and (D) Fragments Per Kilobase of transcript per Million (FPKM) of genes affected in EGF signaling pathway. p < 0.05 was considered as statistically significant.
Authors: Eric N. Aguilar, Satish Sagar, Brandy R. Murray, Christabelle Rajesh, Eric K. Lei, Sarah A. Michaud, David R. Goodlett, Thomas C. Caffrey, Paul M. Grandgenett, Benjamin Swanson, Teresa M. Brooks, Adrian R. Black, Henk van Faassen, Greg Hussack, Kevin A. Henry, Michael A. Hollingsworth, Cory L. Brooks, Prakash Radhakrishnan
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4399338996