Supplementary Figure S4 from Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6
Year: 2024
Type: supplementary-materials
Abstract: Fig. S4. huAR9.6 effects on PDAC cells and PDXs. Representative wound healing assay of vehicle (PBS), isotype control huIgG (40 µg/mL) and huAR9.6 (40 µg/mL) treated (A) T3M4 and (B) Capan-1 cells. (C) Schematic of patient-derived xenograft (PDX) derived cells obtained from primary human PDAC and liver metastasis. (D) Flow cytometric assessment of apoptosis using the Annexin-V/PI assay in T3M4 and Capan-1 cells treated with vehicle (PBS), isotype control huIgG (40 µg/mL) and huAR9.6 (40 µg/mL). Mean ± SD (n=3), p < 0.05 was considered as statistically significant using one-way ANOVA with Tukey’s multiple comparisons.
Authors: Eric N. Aguilar, Satish Sagar, Brandy R. Murray, Christabelle Rajesh, Eric K. Lei, Sarah A. Michaud, David R. Goodlett, Thomas C. Caffrey, Paul M. Grandgenett, Benjamin Swanson, Teresa M. Brooks, Adrian R. Black, Henk van Faassen, Greg Hussack, Kevin A. Henry, Michael A. Hollingsworth, Cory L. Brooks, Prakash Radhakrishnan
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4399340108