Supplementary Figure S10 from Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6
Year: 2024
Type: supplementary-materials
Abstract: Fig. S10. Conservation of AR9.6 epitope in homologous SEA domains. The epitope deduced from the X-ray structure of AR9.6 in complex with SEA5 (yellow ribbon diagram) occurs in 3 regions of the protein (shown in orange). (A) Alignment of SEA5 with homologous MUC16 SEA domains reveals that the epitope is well conserved among SEA domains 3-13, (B) less well conserved in SEA domains 1-2 (C), and the least conserved in SEA domains 13,14,16. (D) No significant epitope conservation occurs in SEA domain 15.
Authors: Eric N. Aguilar, Satish Sagar, Brandy R. Murray, Christabelle Rajesh, Eric K. Lei, Sarah A. Michaud, David R. Goodlett, Thomas C. Caffrey, Paul M. Grandgenett, Benjamin Swanson, Teresa M. Brooks, Adrian R. Black, Henk van Faassen, Greg Hussack, Kevin A. Henry, Michael A. Hollingsworth, Cory L. Brooks, Prakash Radhakrishnan
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4399342813