Year: 2024
Type: article
Abstract: transcatheter aortic valve replacement; stroke Despite reductions in procedure-related mortality and complications, 1 stroke remains a persistent complication after transcatheter aortic valve replacement (TAVR).However, only disabling strokes are associated with increased mortality post-TAVR, whereas nondisabling strokes are not. 2 Consequently, only disabling stroke has been included in the composite endpoint for recent TAVR clinical trials.The distinction between disabling and non-disabling stroke post-TAVR is further highlighted by the PROTECTED-TAVR trial, which demonstrated a potential benefit of cerebral embolic protection on disabling stroke but not for the primary endpoint of any stroke.3 Given these differences in outcomes and preventive strategies, it is important to understand the severity of post-TAVR strokes that occur in clinical practice.While formal neurologic adjudication is frequently used in clinical trials, this approach is impractical outside of the trial setting.The TVT registry only captures stroke in aggregate, administrative claims do not specify functional status after stroke, and attempts to collect more detailed information on stroke severity in other national registries have been unsuccessful owing to frequent missing data.As such, it is challenging to distinguish between disabling and non-disabling strokes after TAVR using real-world data.
Authors: Neel M. Butala, Samir R. Kapadia, Robert W. Yeh, David J. Cohen
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4399363902