Work

A Λ -Ir( iii )-phenylquinazolinone complex enhances ferroptosis by selectively inhibiting metallothionein-1

Year: 2024

Type: article

Abstract: -IrPPQ achieved precise regulation of ferroptosis in pancreatic cancer cells. This work provides new insights into the design of chiral ferroptosis-inducing metallodrugs for future pancreatic cancer therapy.

Source: Chemical Science

DOI: 10.1039/d4sc00422a

Authors: Lu Zhu, Xingyun Wang, Xingyun Wang, Tian Tian, Yanyan Chen, Wenjing Du, Wei Wei, Jing Zhao, Zijian Guo, Xiuxiu Wang, Xiuxiu Wang

Institution: Nanjing University

Language: English

Topic: Ferroptosis and cancer prognosis

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Government of Jiangsu Province, Natural Science Foundation of Jiangsu Province, Nanjing Science and Technology Commission, National Key Research and Development Program of China

Awards: G127490448, G2032020813, G2976407989, G3029743800, G3192847113, G462353024, G5650812686, G8126516475, G8814059172, G8816350880

OpenAlex ID: W4399407676

FWCI: 4.258

Cites: 46

Cited by: 17

Related to: 10