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Invasive squamous cell carcinoma arising from an intraductal oncocytic papillary neoplasm demonstrating shared ATP1B1::PRKACA gene fusion

Year: 2024

Type: article

Abstract: Intraductal oncocytic papillary neoplasms (IOPN) are rare cystic pancreatic neoplasms marked by oncocytic cells and intricate papillary structures. While typically slow-growing, approximately one-third of IOPN cases are associated with invasive adenocarcinoma. In this report, we present an extremely rare case of invasive squamous cell carcinoma arising in the background of IOPN. A 74-year-old man underwent a central pancreatectomy due to an incidentally discovered cystic mass in the pancreatic body. Histological examination revealed IOPN with regions of invasive squamous cell carcinoma. Next-generation sequencing identified the characteristic ATP1B1::PRKACA fusion in both the IOPN and squamous cell carcinoma components. To the best of our knowledge, this is the first documented instance of invasive squamous cell carcinoma originating from an IOPN.

Source: Human Pathology Reports

DOI: 10.1016/j.hpr.2024.300745

Authors: Wai Szeto, Safa Alshaikh, Javier A. Arias-Stella, Yuman Fong, Rifat Mannan

Institutions: City Of Hope National Medical Center, Salmaniya Medical Complex, Arabian Gulf University

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,090