Associations between perinatal risk and physical health in pre-adolescence in the Adolescent Brain Cognitive Development (ABCD) Study®: the unexpected relationship with sleep disruption
Year: 2024
Type: article
Abstract: BACKGROUND: To investigate relationships among different physical health problems in a large, sociodemographically diverse sample of 9-to-10-year-old children and determine the extent to which perinatal health factors are associated with childhood physical health problems. METHODS: A cross-sectional study was conducted utilizing the Adolescent Brain Cognitive Development℠ (ABCD) Study (n = 7613, ages 9-to-10-years-old) to determine the associations among multiple physical health factors (e.g., prenatal complications, current physical health problems). Logistic regression models controlling for age, sex, pubertal development, household income, caregiver education, race, and ethnicity evaluated relationships between perinatal factors and childhood physical health problems. RESULTS: There were significant associations between perinatal and current physical health measures. Specifically, those who had experienced perinatal complications were more likely to have medical problems by 9-to-10 years old. Importantly, sleep disturbance co-occurred with several physical health problems across domains and developmental periods. CONCLUSION: Several perinatal health factors were associated with childhood health outcomes, highlighting the importance of understanding and potentially improving physical health in youth. Understanding the clustering of physical health problems in youth is essential to better identify which physical health problems may share underlying mechanisms. IMPACT: Using a multivariable approach, we investigated the associations between various perinatal and current health problems amongst youth. Our study highlights current health problems, such as sleep problems at 9-to-10 years old, that are associated with a cluster of factors occurring across development (e.g., low birth weight, prenatal substance exposure, pregnancy complications, current weight status, lifetime head injury). Perinatal health problems are at large, non-modifiable (in this retrospective context), however, by identifying which are associated with current health problems, we can identify potential targets for intervention and prevention efforts.
Source: Pediatric Research
Authors: Shana Adise, Clare E. Palmer, Chandni Sheth, Andrew T. Marshall, Fiona C. Baker, Sandra A. Brown, Linda Chang, Duncan B. Clark, Rada K. Dagher, Vanessa Diaz, Frank Haist, Megan M. Herting, Rebekah S. Huber, Kimberly LeBlanc, Karen C. Lee, Huajan Liang, Janosch Linkersdörfer, Krista M. Lisdahl, Jiyoung Ma, Gretchen Neigh, Megan W. Patterson, Perry Renshaw, Kyung E. Rhee, Calen Smith, Susan F. Tapert, Wesley K. Thompson, Kristina A. Uban, Deborah Yurgelun-Todd, Elizabeth R. Sowell
Institutions: University of Southern California, Children's Hospital of Los Angeles, University of California San Diego, University of Utah, SRI International, University of Maryland, Baltimore, University of Pittsburgh, National Institute on Drug Abuse, National Institute on Minority Health and Health Disparities, Eunice Kennedy Shriver National Institute of Child Health and Human Development, University of Wisconsin–Milwaukee, Virginia Commonwealth University, University of Colorado Anschutz, University of Colorado Denver, Laureate Institute for Brain Research, University of California, Irvine
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,390
Funders: U.S. Department of Health and Human Services, National Institutes of Health, Saban Research Institute, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Minority Health and Health Disparities
Awards: G1020259976, G1023219283, G1058358382, G1082956088, G1088205697, G1436251778, G1510635755, G1569016918, G1586463187, G1742849658, G2715786902, G2735337927, G2998093352, G3305455594, G343603955, G3438786812, G3563224455, G3674756438, G3738900353, G3755973507, G4066048162, G4180929035, G4241744443, G4611176450, G469525291, G5002640097, G5081895789, G5139799579, G515074673, G5976565686, G687916792, G6887863799, G6922259526, G6983123888, G7271102572, G7315523460, G7652160222, G771167098, G7723913327, G815084465, G8281824583, G8679417706, G8762821959, G8865478933, G89476839, G9000006386, G9000008241, G9000025347, G9000034221, G9000042425, G9000046731, G9000061868, G9000108491, G9000112882, G9000113866, G9000163168, G9000202101, G9000205938, G9000241459, G9000286149, 9/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MICHIGAN, 17/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UCLA, 8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA, 6/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT OHSU, 21/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT WUSTL, 2/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UMB, G923039674
OpenAlex ID: W4399465267