Toward Next-Generation Molecular Imaging with a Clinical Low-Field (0.064 T) Point-of-Care MRI Scanner
Year: 2024
Type: article
Abstract: Low-field (LF) MRI promises soft-tissue imaging without the expensive, immobile magnets of clinical scanners but generally suffers from limited detection sensitivity and contrast. The sensitivity boost provided by hyperpolarization can thus be highly synergistic with LF MRI. Initial efforts to integrate a continuous-bubbling SABRE (signal amplification by reversible exchange) hyperpolarization setup with a portable, point-of-care 64 mT clinical MRI scanner are reported. Results from 1 H SABRE MRI of pyrazine and nicotinamide are compared with those of benchtop NMR spectroscopy. Comparison with MRI signals from samples with known H 2 O/D 2 O ratios allowed quantification of the SABRE enhancements of imaged samples with various substrate concentrations (down to 3 mM). Respective limits of detection and quantification of 3.3 and 10.1 mM were determined with pyrazine 1 H polarization ( P H ) enhancements of ∼1900 ( P H ∼0.04%), supporting ongoing and envisioned efforts to realize SABRE-enabled MRI-based molecular imaging.
Source: Analytical Chemistry
Authors: Nadiya Iqbal, Drew O. Brittin, Praveen J. Daluwathumullagamage, Md Shahabuddin Alam, Ishani M. Senanayake, A. Tobi Gafar, Zahid Siraj, Anthony Petrilla, Margaret Pugh, Brockton Tonazzi, Sudarshan Ragunathan, Megan E. Poorman, Laura Sacolick, Thomas Theis, Matthew S. Rosen, Eduard Y. Chekmenev, Boyd M. Goodson
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Funders: National Science Foundation, U.S. Department of Defense, Massachusetts General Hospital, North Carolina State University, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Biomedical Imaging and Bioengineering, Division of Materials Research, Division of Chemistry, Congressionally Directed Medical Research Programs
Awards: G1273940453, LOW-COST, HIGH-THROUGHPUT 3D PULMONARY IMAGING USING HYPERPOLARIZED PROPANE GAS, G2005036066, Molecular MRI of Brain Metabolism Enabled by Long-Lived Spin States, G4119534169, Rapid low-cost production of contrast agents for metabolic imaging, REU Site in Interdisciplinary Materials Research, G561024176, Low-Cost, High-Throughput 3D Pulmonary Imaging Using Hyperpolarized Propane Gas, G5850682332, G596555798, Low-Cost, High-Throughput 3D Pulmonary Imaging Using Hyperpolarized Propane Gas, Collaborative Research: Exploiting Spin Networks and Efficient Catalyst/Substrate Separations for NMR "SABRE" Enhancement of Complex Systems, Collaborative Research: Exploiting Spin Networks and Efficient Catalyst/Substrate Separations for NMR "SABRE" Enhancement of Complex Systems, G7873032215, G8890004395, G8940636334, Plug-and-play Hyperpolarized MRI of Metabolism on Clinical Scanners, G963675483
OpenAlex ID: W4399485384