Work

FXR deletion attenuates intestinal barrier dysfunction in murine acute intestinal inflammation

Year: 2024

Type: article

Abstract: Intestinal barrier failure is a hallmark in gut-origin sepsis. We demonstrate that the intestinal barriers of farnesoid-X receptor (FXR) knockout (KO) animals are protected from inflammatory insult using multiple models of acute intestinal inflammation. This protection is due to decreased inflammatory cytokine production and maintenance of tight junctional architecture seen within the KO animals. This is the first report of FXR deletion being protective to the intestinal barrier.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00063.2024

Authors: MaKayla L. O’Guinn, David A. Handler, Jonathan J. Hsieh, Michael U. Mallicote, Karina Feliciano, Christopher P. Gayer

Institutions: University of Southern California, Children's Hospital Los Angeles, Saban Research Institute

Language: English

Topic: Gastrointestinal motility and disorders

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases