Work

Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids

Year: 2025

Type: article

Source: Nature Biotechnology

DOI: 10.1038/s41587-025-02556-5

Authors: Manthan N. Patel, Sachchidanand Tiwari, Yufei Wang, Sarah O’Neill, Jichuan Wu, Serena Omo-Lamai, Carolann Espy, Liam S. Chase, Aparajeeta Majumder, Evan Hoffman, Anit Shah, András Sárközy, Jeremy Katzen, Norbert Pardi, Jacob S. Brenner

Institution: University of Pennsylvania

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases

Awards: Understanding how alveolar epithelial cell stress drives aberrant repair in interstitial lung disease, Small Molecule Drug-Loaded RNA Lipid Nanoparticles for the Treatment of Intracerebral Hemorrhage, Nanomedicine for ARDS: A new paradigm to target drugs to multiple cell types within alveolar capillaries, Controlling complement to unleash nanomedicine for acute critical illnesses, NRSA Training Core, Lipid nanoparticle adjuvants for mRNA vaccines: composition-function relation and mechanism of action, TRAINING IN PULMONARY IMMUNOLOGY, mRNA-LNPs for ARDS

OpenAlex ID: W4407150836

FWCI: 25.96

Cites: 36

Cited by: 88

Related to: 10