Work

Improved Rigidin-Inspired Antiproliferative Agents with Modifications on the 7-Deazahypoxanthine C7/C8 Ring Systems

Year: 2024

Type: article

Abstract: , the new derivatives were also potent inhibitors of tubulin assembly. In treated HeLa cells, live cell confocal microscopy demonstrated their impact on microtubulin dynamics and spindle morphology, which is the upstream trigger of mitotic delay and cell death.

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.3c02473

Authors: Aletta E. van der Westhuyzen, Naghmana Ashraf, Daleen Conradie, Leigh Loots, Catherine H. Kaschula, Stephen C. Pelly, Liliya V. Frolova, Taylor Landfair, Charles B. Shuster, Tania Betancourt, Alexander Kornienko, Willem A. L. van Otterlo

Institutions: Stellenbosch University, New Mexico State University, Emory University, Texas State University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Texas State University, New Mexico State University, Department of Science and Innovation, South Africa, National Research Foundation, Universiteit Stellenbosch, National Institutes of Health, National Institute of General Medical Sciences

Awards: G4745189739, G5385223092, G5785428486, G6648838348, G7022133361, G9000246188, G-RISE at New Mexico State University, Parameters that determine cell fate during mitotic arrest

OpenAlex ID: W4399567094

FWCI: 0.289

Cites: 67

Cited by: 2

Related to: 10