Reviewer #1 (Public Review): Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity
Year: 2024
Type: peer-review
Abstract: The adaptive T cell response is accompanied by continuous rewiring of the T cell’s electric and metabolic state. Ion channels and nutrient transporters integrate bioelectric and biochemical signals from the environment, setting cellular electric and metabolic states. Divergent electric and metabolic states contribute to T cell immunity or tolerance. Here, we report that neuritin (Nrn1) contributes to tolerance development by modulating regulatory and effector T cell function. Nrn1 expression in regulatory T cells promotes its expansion and suppression function, while expression in the T effector cell dampens its inflammatory response. Nrn1 deficiency causes dysregulation of ion channel and nutrient transporter expression in Treg and effector T cells, resulting in divergent metabolic outcomes and impacting autoimmune disease progression and recovery. These findings identify a novel immune function of the neurotrophic factor Nrn1 in regulating the T cell metabolic state in a cell context-dependent manner and modulating the outcome of an immune response.
Institutions: Roswell Park Comprehensive Cancer Center, Johns Hopkins University, National Health Research Institutes, University of Pittsburgh, Dalian Medical University, Keio University, Columbia University Irving Medical Center, Johns Hopkins Medicine, Chang Gung Memorial Hospital, Linkou Chang Gung Memorial Hospital, Sidney Kimmel Comprehensive Cancer Center, Herbert Irving Comprehensive Cancer Center, Carnegie Mellon University, Columbia University
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4399574358