Work

Dietary fiber supplementation increases Drosophila melanogaster lifespan and gut microbiota diversity

Year: 2024

Type: article

Abstract: genes in the gut of older flies, possibly delaying the gut dysbiosis connected to the age-related gut immune dysfunction. Brain proteome analysis showed that DFS led to the modulation of metabolic processes connected to mitochondrial biogenesis, the RhoV-GTPase cycle, organelle biogenesis and maintenance, membrane trafficking and vesicle-mediated transport, possibly orchestrated through a gut-brain axis interaction. Taken together, our study shows that DFS can prolong the half-life and lifespan of flies, possibly by promoting a healthier gut environment and delaying the physiological dysbiosis that characterizes the ageing process. However, the RhoV-GTPase cycle at the brain level may deserve more attention in future studies.

Source: Food & Function

DOI: 10.1039/d4fo00879k

Authors: Daniela Beghelli, Laura Giusti, Lorenzo Zallocco, Maurizio Ronci, Alessia Cappelli, Matthew G. Pontifex, Michael Muller, Claudia Damiani, Ilenia Cirilli, Silvana Hrelia, David Vauzour, Elena Vittadini, Guido Favia, Cristina Angeloni

Institutions: Università di Camerino, University of Pisa, University of Chieti-Pescara, University of East Anglia, Marche Polytechnic University, University of Bologna

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4399588666

FWCI: 1.211

Cites: 57

Cited by: 10

Related to: 10