Differential expression of HIF-1α and its hypoxia-related inducers in the spleens of plateau yaks and plain yellow cattle.
Year: 2025
Type: article
Abstract: <0.05). In conclusion, combining the differences in spleen tissue structure, glycogen distribution, and expression distribution of several hypoxia-related factors between yaks and cattle, we suggest that HIF-1α, VEGF, VEGFR-2, VCAM-1, and IL-4 may be important factors in the adaptation of yak spleen to the plateau environment, which provides a theoretical basis for further exploring the adaptation mechanism of plateau hypoxia in yaks.
Source: PubMed
DOI: 10.14670/hh-18-768
Authors: Manlin Zhou, Shihui Dong, Jun Wang, Xuehui Luo, Rui Li, Yiyang Zhang, Haie Ding, Xiao Tan, Zilin Qiao, Kun Yang, Weiji Chen
Institutions: Northwest Minzu University, State Ethnic Affairs Commission
Language: English
Topic: High Altitude and Hypoxia
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4399597419