Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis
Year: 2024
Type: article
Study design: Observational Study
Abstract: Smooth pursuit eye movements are considered a well-established and quantifiable biomarker of sensorimotor function in psychosis research. Identifying psychotic syndromes on an individual level based on neurobiological markers is limited by heterogeneity and requires comprehensive external validation to avoid overestimation of prediction models. Here, we studied quantifiable sensorimotor measures derived from smooth pursuit eye movements in a large sample of psychosis probands (N = 674) and healthy controls (N = 305) using multivariate pattern analysis. Balanced accuracies of 64% for the prediction of psychosis status are in line with recent results from other large heterogenous psychiatric samples. They are confirmed by external validation in independent large samples including probands with (1) psychosis (N = 727) versus healthy controls (N = 292), (2) psychotic (N = 49) and non-psychotic bipolar disorder (N = 36), and (3) non-psychotic affective disorders (N = 119) and psychosis (N = 51) yielding accuracies of 65%, 66% and 58%, respectively, albeit slightly different psychosis syndromes. Our findings make a significant contribution to the identification of biologically defined profiles of heterogeneous psychosis syndromes on an individual level underlining the impact of sensorimotor dysfunction in psychosis.
Source: Scientific Reports
Authors: Inga Meyhoefer, Andreas Sprenger, David Derad, Dominik Grotegerd, Ramona Leenings, Elisabeth J. Leehr, Fabian Breuer, Marian Surmann, Karen Rolfes, Volker Arolt, Georg Romer, Markus Lappe, Johanna Rehder, Nikolaos Koutsouleris, Stefan Borgwardt, Frauke Schultze-Lutter, Eva Meisenzahl, Tilo T. J. Kircher, Sarah S. Keedy, Jeffrey R. Bishop, Elena I. Ivleva, Jennifer E. McDowell, James L. Reilly, Scot Kristian Hill, Godfrey D. Pearlson, Carol A. Tamminga, Matcheri S. Keshavan, Elliot S. Gershon, Brett A. Clementz, John A. Sweeney, Tim Hahn, Udo Dannlowski, Rebekka Lencer
Institutions: University of Münster, Heinrich Heine University Düsseldorf, University of Lübeck, King's College London, Max Planck Institute of Psychiatry, Ludwig-Maximilians-Universität München, University of Basel, University Hospital of Basel, University of Bern, Universitas Airlangga, Philipps University of Marburg, University of Chicago, University of Minnesota, The University of Texas Southwestern Medical Center, University of Georgia, Northwestern University, Rosalind Franklin University of Medicine and Science, Hartford Hospital, Yale University, Beth Israel Deaconess Medical Center, Harvard University, Sichuan University, West China Hospital of Sichuan University, University of Cincinnati
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,590
OpenAlex ID: W4399700759