Supplementary Figure 6 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Year: 2024
Type: supplementary-materials
Abstract: Supplementary Figure 6: Gut Microbiome Dynamics During Neoadjuvant Chemotherapy A: Relative abundance of major bacterial genera before, during, and after chemotherapy. Each color represents a different genus, with patient-specific changes highlighted to illustrate shifts in microbial composition over the course of treatment. B: Violin plots representing alpha diversity indices (ACE, Chao1, Observed, Pielou, Shannon, and Simpson) at three stages of chemotherapy: before, during, and after treatment. C: Cladogram derived from LEfSe analysis illustrating the most significantly altered taxa at each treatment stage. Colored nodes indicate taxa with statistically significant differences in abundance, with arrows highlighting key changes before, during, and after chemotherapy. D: Each segment shows the percentage composition of each genus by treatment stage. E: Venn diagram summarizing the overlap and unique bacterial taxa found at each stage of chemotherapy, quantifying shared and exclusive genera before, during, and after treatment. F: Principal Coordinates Analysis (PCoA) plot based on weighted UniFrac distances, showing the clustering of microbial communities at different treatment stages. G: Bar graph illustrating the proportional changes in specific bacterial genera over the course of chemotherapy, quantified and compared across three phases.
Authors: Laura Bukavina, Rashida Ginwala, Mohamed Eltoukhi, Mohit Sindhani, Megan Prunty, Daniel M. Geynisman, Pooja Ghatalia, Henkel Valentine, Adam Calaway, Andres F. Correa, Jason R. Brown, Kirtishri Mishra, Elizabeth R. Plimack, Alexander Kutikov, Mahmoud Ghannoum, Mohammed Elshaer, Mauricio Retuerto, Lee Ponsky, Robert G. Uzzo, Philip H. Abbosh
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4399736452