Supplementary Figure 9 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Year: 2024
Type: supplementary-materials
Abstract: Supplementary Figure 9: Microbial Composition Variability by Sex in BBN-Exposed Mice BBN Gender Female: A: Alpha diversity indices (ACE, Chao1, Shannon) across different time points (0, 6, 12, 16-22 weeks), showing variations in microbial diversity in female mice. B: Stacked bar chart illustrating the relative abundance of bacterial genera at each time point. C: Dot plot depicting the percentage of specific bacterial families at different time points, providing a quantitative view of how predominant families fluctuate with BBN exposure. D: Principal Coordinates Analysis (PCoA) plot based on weighted UniFrac distances, showing the clustering of microbial communities across time, with color-coded points representing different time points to visualize the trajectory of community changes. E: Bar chart with Linear Discriminant Analysis (LDA) scores of bacterial taxa that are significantly different across the studied time points. BBN Gender Male: F: Alpha diversity indices (ACE, Chao1, Shannon) displayed across the same time points as the female group, illustrating the microbial diversity dynamics in male mice. G: Stacked bar chart showing the relative abundance of bacterial genera in male mice, and the specific microbial shifts unique to male physiology under BBN influence. H: Dot plot of the percentage representation of bacterial families over time, helps in identifying sex-specific microbial behavior in response to carcinogenic treatment. I: PCoA plot for the male group, illustrating shifts in microbial community structure with different clusters for each time point. J: LDA score bar chart for male mice displaying significant microbial taxa changes over time providing insight on impact of BBN exposure on the male gut microbiome.
Authors: Laura Bukavina, Rashida Ginwala, Mohamed Eltoukhi, Mohit Sindhani, Megan Prunty, Daniel M. Geynisman, Pooja Ghatalia, Henkel Valentine, Adam Calaway, Andres F. Correa, Jason R. Brown, Kirtishri Mishra, Elizabeth R. Plimack, Alexander Kutikov, Mahmoud Ghannoum, Mohammed Elshaer, Mauricio Retuerto, Lee Ponsky, Robert G. Uzzo, Philip H. Abbosh
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4399736599