Work

Design, synthesis and antitumor activity of a novel FGFR2-selective degrader to overcome resistance of the FGFR2V564F gatekeeper mutation based on a pan-FGFR inhibitor

Year: 2024

Type: article

Source: European Journal of Medicinal Chemistry

DOI: 10.1016/j.ejmech.2024.116612

Authors: Zuli Hu, Qiangsheng Zhang, Zulong Li, Hongling Yang, Xin Chen, Qi Zhang, Tianqiong Yang, Xiaojie He, Qiang Feng, Jun He, Luoting Yu

Institutions: Sichuan University, West China Medical Center of Sichuan University, West China Hospital of Sichuan University, State Key Laboratory of Biotherapy, Southwest Jiaotong University, Chengdu Normal University

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Department of Science and Technology of Sichuan Province, Sichuan Province Science and Technology Support Program

Award: G4448598666

OpenAlex ID: W4399762041

FWCI: 1.941

Cites: 33

Cited by: 15

Related to: 10