A very complicated UTI: malakoplakia following E. coli urinary tract infection
Year: 2024
Type: article
Study design: Case Report
Abstract: Malakoplakia is a rare inflammatory disorder believed to result from a defect in macrophage phagocytic function triggering a granulomatous reaction. It can present with genitourinary, gastrointestinal, or cutaneous manifestations in immunocompromised or, less commonly, immunocompetent hosts. We describe a case of renal malakoplakia in a young, otherwise healthy patient presenting with nephromegaly and sepsis following an E. coli urinary tract infection. We discuss diagnosis and management, including antibiotic selection and the decision to pursue nephrectomy. This case highlights the potential for kidney recovery with prolonged antibiotic therapy in conjunction with adjunct immunomodulatory therapies and source control.
Source: BMC Nephrology
Authors: Ayotola Fatola, Benjamin C. Johnson, Laura Walsh, Diana Fang, Marissa J. White, Dustin Le, Mohamed G. Atta, C. John Sperati, David N. Hager
Institutions: Johns Hopkins University, Johns Hopkins Medicine
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,890
OpenAlex ID: W4399770619