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Figure S4 from HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity

Year: 2024

Type: other

Abstract: Fig. S4. a. Effect of hits from the HTS on proteasome ChT-like activity on ARH-77 and U266 MMCLs. Proteasome ChT-like activity was determined with 50,000 ARHG-77 or U266 cells/well after 24 h of incubation with 50 uM LLVY-R110. b. Effect of proteasome inhibitors on proteasome ChT-like activity in three different MMCLs. Bortezomib, carfilzomib and ixazomib were added to MM cells at indicated concentrations. Proteasome ChT-like activity was then determined after 24 h incubation.

DOI: 10.1158/2767-9764.26058194

Authors: Priyanka S. Rana, James J. Ignatz-Hoover, Byung-Gyu Kim, Ehsan Malek, Yuriy Federov, Drew Adams, Timothy Chan, James J. Driscoll

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4399772014

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