Position paper of the Italian Association for the Study of the Liver (AISF): Management and treatment of primary biliary cholangitis
Year: 2024
Type: article
Abstract: Primary biliary cholangitis (PBC) is an autoimmune chronic cholestatic liver disease characterized by immune-mediated inflammation and destruction of the intrahepatic, small bile ducts. In PBC patients untreated or under-treated a progressive cholestasis leads to biliary fibrosis and ultimately liver cirrhosis. Disease presentation may differ within a wide spectrum, particularly based on the stage of the disease at onset; from asymptomatic, in most cases, or symptomatic, typically with pruritus and/or fatigue; jaundice may be present at presentation due to late diagnosis at cirrhotic stage or due to a premature severe ductopenia.
Source: Digestive and Liver Disease
Institutions: Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, University of Milano-Bicocca, Sapienza University of Rome, University of Padua, Azienda Ospedale - Università Padova, Federico II University Hospital, University of Naples Federico II, Humanitas University, IRCCS Humanitas Research Hospital, Università Cattolica del Sacro Cuore, Agostino Gemelli University Polyclinic, Istituti di Ricovero e Cura a Carattere Scientifico, Marche Polytechnic University, Azienda Ospedaliero-Universitaria delle Marche, Istituto Nazionale Biostrutture e Biosistemi, University of Bari Aldo Moro, IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola, University of Bologna, Università degli Studi del Piemonte Orientale “Amedeo Avogadro”, Azienda Ospedaliero Universitaria Maggiore della Carita, Università Campus Bio-Medico, Campus Bio Medico University Hospital, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Palermo
Language: English
Topic: Liver Diseases and Immunity
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,300
OpenAlex ID: W4399797763