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Crystal structure of MAGEA4 MHD-RAD18 R6BD reveals a flipped binding mode compared to AlphaFold2 prediction

Year: 2024
Type: letter
DOI: 10.1038/s44318-024-00140-2
Authors: Karly Forker, Matthew C Fleming, Kenneth H Pearce, Cyrus Vaziri, Albert A Bowers, Pei Zhou
Language: English
Open Access status: gold
Estimated APC paid: $6,890
Funders: U.S. Department of Energy, National Institutes of Health, Office of Science, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Environmental Health Sciences, Argonne National Laboratory
Awards: G102163711, Establishing MAGE-A4/RAD18 as a novel cancer-specific chemotherapeutic target, G107546177, G1313983767, G1664757510, G2287611682, G262962599, G2733399964, G3075337988, G409777406, G4155925329, G4429385918, G498139845, G5607048534, G5758348842, G6848031779, G6918803902, G7612180383, G78868261, G9000051782, UNC Center for Environmental Health and Susceptibility, Inhibiting Rev1-mediated translesion DNA synthesis for cancer therapy, Chemoenzymatic Synthesis, Mode of Action and Evolution of Natural Product-based Macrocycles, NE-CAT: A Resource for Advanced Macromolecular Crystallography, G969889393, G993149817
OpenAlex ID: W4399884314
Cites: 9
Cited by: 4
Related to: 2