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Association of the gut microbiome with kidney function and damage in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Year: 2023
Type: article
Study design: Observational Study
Abstract: Background The gut microbiome is altered in chronic kidney disease (CKD), potentially contributing to CKD progression and co-morbidities, but population-based studies of the gut microbiome across a wide range of kidney function and damage are lacking.Methods In the Hispanic Community Health Study/Study of Latinos, gut microbiome was assessed by shotgun sequencing of stool (n = 2,438; 292 with suspected CKD). We examined cross-sectional associations of estimated glomerular filtration rate (eGFR), urinary albumin:creatinine (UAC) ratio, and CKD with gut microbiome features. Kidney trait-related microbiome features were interrogated for correlation with serum metabolites (n = 700), and associations of microbiome-related serum metabolites with kidney trait progression were examined in a prospective analysis (n = 3,635).Results Higher eGFR was associated with overall gut microbiome composition, greater abundance of species from Prevotella, Faecalibacterium, Roseburia, and Eubacterium, and microbial functions related to synthesis of long-chain fatty acids and carbamoyl-phosphate. Higher UAC ratio and CKD were related to lower gut microbiome diversity and altered overall microbiome composition only in participants without diabetes. Microbiome features related to better kidney health were associated with many serum metabolites (e.g., higher indolepropionate, beta-cryptoxanthin; lower imidazole propionate, deoxycholic acids, p-cresol glucuronide). Imidazole propionate, deoxycholic acid metabolites, and p-cresol glucuronide were associated with prospective reductions in eGFR and/or increases in UAC ratio over ~6 y.Conclusions Kidney function is a significant correlate of the gut microbiome, while the relationship of kidney damage with the gut microbiome depends on diabetes status. Gut microbiome metabolites may contribute to CKD progression.
Source: Gut Microbes
DOI: 10.1080/19490976.2023.2186685
Authors: Brandilyn A. Peters, Qibin Qi, Mykhaylo Usyk, Martha L. Daviglus, Jianwen Cai, Nora Franceschini, James P. Lash, Marc D. Gellman, Bing Yu, Eric Boerwinkle, Rob Knight, Robert D. Burk, Robert C. Kaplan
Institutions: Albert Einstein College of Medicine, University of Illinois Chicago, University of North Carolina at Chapel Hill, University of Miami, The University of Texas Health Science Center at Houston, University of California San Diego, Fred Hutch Cancer Center
Language: English
Open Access status: gold
Estimated APC paid: $3,060
Funders: University of Miami, University of North Carolina, San Diego State University, National Institutes of Health, University of Illinois at Chicago, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, National Institute of Dental and Craniofacial Research, National Institute on Minority Health and Health Disparities
Awards: Hispanic Community Health Study, G1666450717, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2528054427, G2970637568, Hispanic Community Health Study, Hispanic Community Health Study, Epidemiology of the gut microbiome, prediabetes and diabetes in Latinos, G528357465, G5365244667, HISPANIC COMMUNITY HEALTH STUDY - COORDINATING CENTER, G6075306088, ChicAgo Center for Health and EnvironmenT (CACHET), New York Regional Center for Diabetes Translation Research
OpenAlex ID: W4323533651
FWCI: 3.718
Cites: 59
Cited by: 43
Related to: 10