Work

Diversity in EWAS: current state, challenges, and solutions

Year: 2022

Type: article

Abstract: Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propose include fostering community involvement, new data generation, and cost-effective approaches such as locus-specific analysis and ancestry variable region analysis.

Source: Genome Medicine

DOI: 10.1186/s13073-022-01065-3

Authors: Charles E. Breeze, Jason Y. Y. Wong, Stephan Beck, Sonja I. Berndt, Nora Franceschini

Institutions: National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, University College London, University of North Carolina at Chapel Hill

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Reduced inequalities

Open Access status: gold

Estimated APC paid: $4,480