Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL
Year: 2024
Type: article
Study design: Observational Study
Abstract: Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central adiposity measured as waist-to-hip ratio (WHR), waist circumference (WC) and hip circumference (HIP) adjusted for body mass index (adjBMI) by using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL); determine if differences in associations differ by background group within HCHS/SOL and determine whether previously reported associations generalize to HCHS/SOL. Our analyses included 7472 women and 5200 men of mainland (Mexican, Central and South American) and Caribbean (Puerto Rican, Cuban and Dominican) background residing in the USA. We performed genome-wide association analyses stratified and combined across sexes using linear mixed-model regression. We identified 16 variants for waist-to-hip ratio adjusted for body mass index (WHRadjBMI), 22 for waist circumference adjusted for body mass index (WCadjBMI) and 28 for hip circumference adjusted for body mass index (HIPadjBMI), which reached suggestive significance (P < 1 × 10-6). Many loci exhibited differences in strength of associations by ethnic background and sex. We brought a total of 66 variants forward for validation in cohorts (N = 34 161) with participants of Hispanic/Latino, African and European descent. We confirmed four novel loci (P < 0.05 and consistent direction of effect, and P < 5 × 10-8 after meta-analysis), including two for WHRadjBMI (rs13301996, rs79478137); one for WCadjBMI (rs3168072) and one for HIPadjBMI (rs28692724). Also, we generalized previously reported associations to HCHS/SOL, (8 for WHRadjBMI, 10 for WCadjBMI and 12 for HIPadjBMI). Our study highlights the importance of large-scale genomic studies in ancestrally diverse Hispanic/Latino populations for identifying and characterizing central obesity susceptibility that may be ancestry-specific.
DOI: 10.17615/0cgr-x282
Authors: Cruz, M., Graff, M., Hsueh, W.A., Taylor, K.D., North, K.E., Isasi, C.R., Tan, J., Petty, L., Raffel, L.J., Gogarten, S.M., Sánchez-Johnsen, L., Sofer, T., Buchanan, T.A., Yao, J., Highland, H.M., Parra, E., Ipp, E., Allison, M.A., Below, J.E., Love, S.A.M., Goodarzi, M.O., Young, K., Guo, X., Justice, A.E., Xiang, A.H., Wang, Y., Chen, Y.-D.I., Palmas, W., Rotter, J.I., Valladares, A., Hartwig, F., Hanis, C., Klimentidis, Y.C.
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: U.S. Department of Health and Human Services, Office of Dietary Supplements, American Heart Association, University of Miami, Northwestern University, San Diego State University, University of Washington, Compute Canada, Instituto Mexicano del Seguro Social, Fundación IMSS, National Institutes of Health, University of Illinois at Urbana-Champaign, Gillings School of Public Health, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Dental and Craniofacial Research, National Center for Research Resources, National Institute on Minority Health and Health Disparities, Compute Ontario
Awards: G1028935811, Mapping Genes for Atherosclerosis and Insulin Resistance, G1081972346, G1085777395, G1114307781, G1140476625, G1201667161, G122677224, G1261793039, G1262629770, G1276754516, G1286721212, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTER, G1312369436, G1327559120, G1360749331, G1446319095, G1455175283, G1462415530, G1516086731, G1522144118, G1522370804, G1558725192, G1640378483, G1740741465, G17630474, G1788514665, G1818487580, G1823732541, G1845395357, Wake Forest Clinical and Translational Science Award, G1866572497, G1888983140, G1984718218, SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER, G2128161193, G2130928551, G2144938473, G2219136675, G22458031, G2262505034, G2312701358, G2375045162, G2391309017, G2462410987, G2466919156, Institute for Clinical and Translational Research (UL1), G2494211023, G2600980409, G2623279087, G2644289446, G2651066328, G2655143993, G2701926366, G2779429302, G2780798618, G2837638605, G290884426, G291913881, G296458788, G3051506083, G3093995152, G3161396180, Genetics at the Interface of Lipid and Glycemic Traits, G3252259982, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTER, G3461750354, G3479217851, G3506141840, G3590818488, G3614733703, G3639969904, GWA for Gene-Environment Interaction Effects Influencing CHD, G3744596180, G3919367648, G3966146196, G3973572274, G3990748671, G4013255670, G4028411927, G4036023366, G4068323944, G4175219461, G4186273061, G4230684217, G432753757, G4438569943, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, G4516765154, G4592244384, G4597579782, G4739409156, G4790942633, G4824239441, G4824283243, G496640596, G5003019801, G5015503974, G508454511, G5102588038, G5129651400, G5223154479, G528357465, G5324596834, G5352314984, G5397198720, Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood, G543802643, Epidemiology of Venous Thrombosis and Pulmonary Embolism, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTER, G5654179670, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTER, G5770678025, G5785169696, G596642789, G5993399974, G6060132884, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY, G6088185517, G6149955053, G6202424770, G6217957645, G6405494218, Institute for Clinical and Translational Research, G658953780, G66341962, G6739173425, G6837735701, G6902273418, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY, G7024443217, G7132511053, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTER, G738160294, G7706274302, G78770644, G7924587209, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, Clinical and Translational Science Award, G818308888, G820454163, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTER, HISPANIC COMMUNITY HEALTH STUDY-268065233, G8852914737, G8930081076, G8987601928, G9000004549, G9000004784, G9000006353, G9000017360, G9000019818, G9000025517, G9000063950, G9000065698, G9000140433, Cardiovascular Epidemiology Training Grant, Hispanic Latino Lipid Consortium, From GWAS loci to blood pressure genes, variants & mechanisms - Renewal, UCLA Clinical and Translational Science Institute, G916230891, G937084196, G991334795
OpenAlex ID: W4400023791