Year: 2024
Type: article
Study design: Observational Study
Abstract: Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genomewide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.
DOI: 10.17615/edv5-cn60
Authors: Southey, M.C., Salles, G., Weinstein, S., Novak, A.J., Holford, T.R., Conde, L., Tinker, L.F., Zelenetz, A., Witzig, T.E., Cerhan, J.R., Boffetta, P., Turner, J., Jackson, R.D., Wang, S.S., Hartge, P., Birmann, B.M., Boeing, H., Monnereau, A., Purdue, M.P., Ramsey-Goldman, R., Clavel, J., Adami, H.-O., Link, B.K., Skibola, C.F., Riby, J., Lan, Q., Klein, R.J., Foretova, L., Ghesquières, H., Severson, R.K., Teras, L.R., Holly, E.A., Giles, G.G., Angelucci, E., Cotenbader, K.H., Tjonneland, A., De Sanjose, S., Zucca, M., Vineis, P., Virtamo, J., Spinelli, J.J., Molina, T.J., Zhang, Y., Kricker, A., Becker, N., Rais, M., Slager, S.L., Severi, G., Lawrence, C., Morton, L.M., Cox, D.G., Wasmann, Y., Zeleniuch-Jacquotte, A., De Roos, A.J., Bracci, P.M., Wang, Z., Tilly, H., Kane, E., Kaaks, R., Di Lollo, S., Bernatsky, S., Clarke, A.E., Glimelius, B., Cozen, W., Ansell, S.M., Zheng, T., Vajdic, C.M., Vermeulen, R.C.H., McKay, J., Brennan, P., Brooks-Wilson, A.R., García, H.A.V., Nieters, A., Gaffney, P., Staines, A., Berndt, S.I., Liebow, M., North, K.E., Roman, E., Benavente, Y., Chanock, S.J., Smith, M.T., Dogan, A., Thompson, C.A., Habermann, T.M., Offit, K., Bertrand, K.A., Maynadie, M., Crouch, S., Kelly, R.S., Melbye, M., Smedby, K.E., Vijai, J., Haioun, C., Albanes, D., Hjalgrim, H., Kraft, P., Smith, A., Diver, W.R., Lightfoot, T., Rothman, N.
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4400024258