Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study
Year: 2018
Type: article
Study design: Observational Study
Abstract: Fructosamine and glycated albumin are potentially useful alternatives to hemoglobin A1c (HbA1c) as diabetes biomarkers. The genetic determinants of fructosamine and glycated albumin, however, are unknown. We performed genome-wide association studies of fructosamine and glycated albumin among 2,104 black and 7,647 white participants without diabetes in the Atherosclerosis Risk in Communities (ARIC) Study and replicated findings in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Among whites, rs34459162, a novel missense single nucleotide polymorphism (SNP) in RCN3, was associated with fructosamine (P = 5.3 × 10−9) and rs1260236, a known diabetes-related missense mutation in GCKR, was associated with percent glycated albumin (P = 5.9 × 10−9) and replicated in CARDIA. We also found two novel associations among blacks: an intergenic SNP, rs2438321, associated with fructosamine (P = 6.2 × 10−9), and an intronic variant in PRKCA, rs59443763, associated with percent glycated albumin (P = 4.1 × 10−9), but these results did not replicate. Few established fasting glucose or HbA1c SNPs were also associated with fructosamine or glycated albumin. Overall, we found genetic variants associated with the glycemic information captured by fructosamine and glycated albumin as well as with their nonglycemic component. This highlights the importance of examining the genetics of hyperglycemia biomarkers to understand the information they capture, including potential glucose-independent factors.
Source: Diabetes
DOI: 10.2337/db17-1362
Institutions: Johns Hopkins University, University of Utah, Johns Hopkins Medicine, University of Alabama at Birmingham, University of North Carolina at Chapel Hill, University of Mississippi Medical Center, The University of Texas Health Science Center at Houston, University of Minnesota, Northwestern University, University of Freiburg, University Medical Center Freiburg
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: U.S. Department of Health and Human Services, Northwestern University, University of Minnesota, Johns Hopkins University, Asahi Kasei Pharma Corporation, Deutsche Forschungsgemeinschaft, National Institutes of Health, Kaiser Foundation Research Institute, Roche Diagnostics, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: G1023103040, G1060904560, G1114307781, G1141534940, G1174177975, G1186962729, G122702767, G1271251741, G1282041129, G1294761135, G1360749331, G1522370804, G1585400806, G1638686622, G172405621, G1752571699, G1774001260, G1788514665, G1804442763, G1823732541, G1848479244, G1913513890, G202194050, G2101392565, G2181497839, G2192100624, G2234140876, G2262505034, G2351218501, G2462410987, G2466882888, Institute for Clinical and Translational Research (UL1), G2607172802, G2642946295, G2750604849, G2780798618, G2967385415, G3051506083, G316474162, G3667954924, GWA for Gene-Environment Interaction Effects Influencing CHD, G3726295381, G3744596180, G3765699373, CANDIDATE GENE ASSOCIATION RESOURCE (CARE), G3973572274, G3984593164, G4031532843, G4036106426, G405311360, G4247981499, G43250720, G443616704, G4516765154, G4562300860, Genome Wide Association Coordinating Center, G4583596103, G4597579782, G4717666138, G4739409156, G4747441672, G4790942633, G4824283243, G4845925406, General Clinical Research Center, G4982075619, G5014201391, G508454511, GWAS of longitudinal blood pressure profiles from young adulthood to middle-age, G510381623, Research and Mentoring in the Clinical Epidemiology of Type 2 Diabetes, G5296600602, G5352314984, Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood, G5565972366, G5617687969, G5622977475, G5663815871, G5770678025, G587882820, G5914762242, G5928944960, G6024098207, G6060132884, Diabetes and Prediabetes in Older Adults in ARIC, G6422240602, G6481268025, G6573031728, G6581345481, G6594067713, G6739173425, G6767999137, G6837735701, G6890907099, G6902273418, G706815212, G7132376052, G7147025221, G7155745631, G7269243931, G7304704001, G7535686976, G7712295779, G7718404950, G7808459314, G7952602228, G8012590081, G8051697962, G8161118679, UAB Center for Clinical and Translational Science (CCTS), The Role of Nontraditional Glycemic Markers in Diabetes and Albuminuria, G8738262636, G89231007, G8996696047, G9000090369, Cardiovascular Epidemiology Institutional Training, From GWAS loci to blood pressure genes, variants & mechanisms - Renewal, UAB Diabetes Research Center, G916230891
OpenAlex ID: W2807572506