Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration
Year: 2020
Type: article
Abstract: BACKGROUND: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. METHODS: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. RESULTS: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). CONCLUSIONS: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.
Source: British Journal of Cancer
Authors: Gioia Di Credico, Jerry Polesel, Luigino Dal Maso, Francesco Pauli, Nicola Torelli, Daniele Luce, Loredana Radoï, Keitaro Matsuo, Diego Serraino, Paul Brennan, Ivana Holcatova, Wolfgang Ahrens, Pagona Lagiou, Cristina Canova, Lorenzo Richiardi, Claire M. Healy, Kristina Kjaerheim, David I. Conway, Gary J. Macfarlane, Peter Thomson, Antonio Agudo, Ariana Znaor, Silvia Franceschi, Rolando Herrero, Tatiana N. Toporcov, Raquel A. Moyses, Joshua Muscat, Eva Negri, Marta Vilensky, Leticia Fernandez, Maria Paula Curado, Ana Menezes, Alexander W. Daudt, Rosalina Koifman, Victor Wunsch-Filho, Andrew F. Olshan, Jose P. Zevallos, Erich M. Sturgis, Guojun Li, Fabio Levi, Zuo-Feng Zhang, Hal Morgenstern, Elaine Smith, Philip Lazarus, Carlo La Vecchia, Werner Garavello, Chu Chen, Stephen M. Schwartz, Tongzhang Zheng, Thomas L. Vaughan, Karl Kelsey, Michael McClean, Simone Benhamou, Richard B. Hayes, Mark P. Purdue, Maura Gillison, Stimson Schantz, Guo-Pei Yu, Shu-Chun Chuang, Paolo Boffetta, Mia Hashibe, Amy Lee Yuan-Chin, Valeria Edefonti
Institutions: University of Trieste, Centro di Riferimento Oncologico, Inserm, École des Hautes Études en Santé Publique, Institut de Recherche en Santé, Environnement et Travail, Université de Rennes, Centre de recherche en Epidémiologie et Santé des Populations, Aichi Cancer Center, Aichi Cancer Center Research Institute, Nagoya University, Centre international de recherche sur le cancer, Charles University, University of Bremen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, National and Kapodistrian University of Athens, University of Padua, University of Turin, Trinity College Dublin, Cancer Registry of Norway, University of Glasgow, University of Aberdeen, University of Hong Kong, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universidade de São Paulo, Pennsylvania State University, University of Milan, Universidad de Buenos Aires, Instituto de Oncología y Radiobiología, AC Camargo Hospital, Universidade Federal de Pelotas, Hospital Moinhos de Vento, Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, University of North Carolina at Chapel Hill, Washington University in St. Louis, Baylor College of Medicine, Institute of Social and Preventive Medicine, Centre universitaire de médecine générale et santé publique, Lausanne, University of Lausanne, University of California, Los Angeles, University of Michigan, Michigan Medicine, University of Iowa, Washington State University Spokane, University of Milano-Bicocca, Fred Hutch Cancer Center, Brown University, Boston University, New York University, National Cancer Institute, Division of Cancer Epidemiology and Genetics, The University of Texas MD Anderson Cancer Center, New York Eye and Ear Infirmary, Peking University, National Health Research Institutes, Tisch Cancer Institute, University of Bologna, Icahn School of Medicine at Mount Sinai, University of Utah, Huntsman Cancer Institute
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,300
Funders: U.S. Department of Veterans Affairs, World Health Organization, Memorial Sloan-Kettering Cancer Center, University of Utah, Università degli Studi di Milano, European Commission, Agence Nationale de la Recherche, Fundação de Amparo à Pesquisa do Estado de São Paulo, Fondation pour la Recherche Médicale, Ministero della Salute, Fondation ARC pour la Recherche sur le Cancer, Oncosuisse, Fondation de France, Ministère des Affaires Sociales et de la Santé, Associazione Italiana per la Ricerca sul Cancro, Institut National Du Cancer, Fondazione Italiana per la Ricerca sul Cancro, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, Institut de Veille Sanitaire, Swiss Cancer Research Foundation, National Institutes of Health, National Institute on Aging, National Institute on Drug Abuse, National Cancer Institute, Fogarty International Center, National Institute of Environmental Health Sciences, National Institute of Dental and Craniofacial Research, Jonsson Comprehensive Cancer Center, Fondo para la Investigación Científica y Tecnológica
Awards: G1008820181, G1017297203, G1067468845, G1131897597, HELICOBACTER PYLORI MALNUTRITION AND GASTRIC CANCER, G1158119171, G1338312080, G1672158201, G1882131324, G1903641494, G2067422786, G2351292984, G2432338990, G2488377645, G2560072748, G2598882791, G2654020657, G2772659363, CARCINOGEN METABOLIZING ENZYMES AND HEAD AND NECK CANCER, G295012831, G2970275439, G2973696938, G3170088140, TOBACCO AND CANCER RISK--DOSE, METABOLISM AND GENETICS, Dual CHIP Functions Control Tau Triage In Alzheimer's Disease, G3475740106, Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas, G36443387, G3702189770, G3708781070, Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe, G4211135087, G4211488925, G426964960, ALCOHOL AND CANCERS OF THE LARYNX AND ESOPHAGUS, UCLA SPORE IN LUNG CANCER, G4417129401, Gene Environment Interaction in Head and Neck Cancer, Sigma Ligands for the Treatment of Cocaine Overdose, G475050224, G479108254, G4923405512, GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER, G504412488, Markers of aggressive behavior in head and neck tumors, UNC-CH CENTER FOR ENVIRONMENTAL HEALTH & SUSCEPTIBILITY, G5810284131, G5870107996, G5956497116, LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERS, G6063816319, ORAL CANCER--EPIDEMIOLOGY, BIOCHEMISTRY, &IMMUNOLOGY, G6414039891, G6446575152, Epidemiology of protein glutathiolation, Molecular Epidemiology and Gene-Environment Interaction, HPV AND RISK OF ORAL CANCER IN THE CZECH REPUBLIC, Spinal Opioid Release in Nociception, G7920079912, ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM, G8101172206, G8124029843, HPV TRANSMISSION AND RISK OF ORAL CANCER, G8338893534, G8362657403, G8515187748, MARIJUANA USE AND THE RISKS OF LUNG AND OTHER CANCERS, Pooled Analyses of SNPs and Risk of Head & Neck Cancer, G879385275, The Boston Collaborative Oral Cancer Study, G9000093046, G9000099626, G9000152497, G9000208888, G9000312689, G9000351518, Synthetic Studies Related to Cancer Research/Treatment, G900952094
OpenAlex ID: W3080618070