Year: 2017
Type: article
Abstract: Human papillomavirus (HPV) causes oropharyngeal squamous cell carcinoma (OPSCC), although strongly divergent results have been reported regarding the prevalence of HPV16 in different countries, whether this represents important differences in etiology remains unclear. Applying rigorous protocols for sample processing, we centrally evaluated 1,420 head and neck tumors (533 oropharynx, 395 oral cavity and 482 larynx) from studies conducted in the US, Europe and Brazil for mucosal HPV DNA and p16 INK4a expression to evaluate regional heterogeneity in the proportion of HPV16‐associated OPSCC and other head and neck cancer, and to assess covariates associated with the risk of HPV16‐positive OPSCC. While majority of OPSCC in the US (60%) were HPV16‐positive, this proportion was 31% in Europe and only 4% in Brazil ( p < 0.01). Similar differences were observed for other head and neck tumors, ranging from 7% in the US and 5% in Europe, to 0% in South America. The odds of HPV16‐positive OPSCC declined with increasing pack years of smoking (OR: 0.75; 95% CI: 0.64–0.87) and drink years of alcohol use (OR: 0.64; 95% CI: 0.54–0.76). These results suggest that while the contribution of HPV16 is substantial for the oropharynx, it remains limited for oral cavity and laryngeal cancers.
Source: International Journal of Cancer
DOI: 10.1002/ijc.30608
Authors: Devasena Anantharaman, Behnoush Abedi‐Ardekani, Daniel C. Beachler, Tarik Gheit, Andrew F. Olshan, Kathy Wisniewski, Victor Wunsch‐Filho, Tatiana N. Toporcov, Eloiza H. Tajara, José Eduardo Levi, Raquel A. Moyses, Stefania Boccia, Gabriella Cadoni, Guido Rindi, Wolfgang Ahrens, Franco Merletti, David I. Conway, Sylvia Wright, Christine Carreira, Helene Renard, Priscilia Chopard, Sandrine McKay‐Chopin, Ghislaine Scelo, Massimo Tommasino, Paul Brennan, Gypsyamber D'Souza
Institutions: Centre international de recherche sur le cancer, National Cancer Institute, Division of Cancer Epidemiology and Genetics, University of North Carolina at Chapel Hill, Universidade de São Paulo, Faculdade de Medicina de São José do Rio Preto, Università Cattolica del Sacro Cuore, University of Bremen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, University of Turin, University of Glasgow, Queen Elizabeth University Hospital, Johns Hopkins University
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Role of human papillomavirus infection and other co-factors in the aetiology of head and neck cancer in India and Europe, Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas, G3698611044, G3699926926, G4113219329, Gene Environment Interaction in Head and Neck Cancer, G479108254, Markers of aggressive behavior in head and neck tumors, G8680805530, G938184179
OpenAlex ID: W2577561171